Premature guinea pigs: a new paradigm to investigate the late-effects of preterm birth. (12th December 2014)

• Record Type: Journal Article
• Authors: Berry, M.; Gray, C.; Wright, K.; Dyson, R.; Wright, I.
• Is Part Of: Journal of developmental origins of health and disease. Volume 6:Number 2(2015)
• Page Start: 143
• Page End: 148
• Publication Date: 2014-12-12
• Subjects: animal models, -- developmental origins of health and disease, -- preterm birth, -- translational biomedical research; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S2040174414000592
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract : Preterm birth is common and the associated short-term morbidity well described. The adult-onset consequences of preterm birth are less clear, but cardiovascular and metabolic health may be adversely affected. Although large animal models of preterm birth addressing important short-term issues exist, long-term studies are hampered by significant logistical constraints. Current small animal models of prematurity require terminal caesarean section of the mother; both caesarean birth and early maternal care modify offspring adult cardio-metabolic function. We describe a novel method for inducing preterm labour in guinea pigs. With support comparable to that received by moderately preterm human infants, preterm pups are viable. Growth trajectories between preterm and term-born pups differ significantly; between term equivalent age and weaning ex-preterm animals demonstrate increased weight and ponderal index. We believe this novel paradigm will significantly improve our ability to investigate the cardio-metabolic sequelae of preterm birth throughout the life course and into the second generation.