A one-pot amidation of primary nitroalkanes. Issue 1 (27th October 2015)

• Record Type: Journal Article
• Authors: Schwieter, Kenneth E.; Johnston, Jeffrey N.
• Is Part Of: Chemical communications. Volume 52:Issue 1(2015)
• Page Start: 152
• Page End: 155
• Publication Date: 2015-10-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08415f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A two-step, one-pot oxidative amidation of primary nitroalkanes involving tandem halogenation/umpolung amide synthesis (UmAS) is described. Abstract : It has been over a half-century since Kornblum demonstrated the conversion of a primary nitroalkane to a carboxylic acid; addition of an amine results in carboxylic acid formation as well. We describe the formation of amides from terminal nitroalkanes in a two-step, one-pot reaction involving tandem halogenation/umpolung amide synthesis (UmAS).