An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Chhabra, Mohit; Sinha, Sohini; Banerjee, Swagata; Paira, Priyankar
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 1(2016)
• Page Start: 213
• Page End: 217
• Publication Date: 2016-01-01
• Subjects: 2-Arylbenzothiazole -- Green chemistry -- Amberlite IR-120 -- Antibacterial agents -- Anticancer agents; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.10.087
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: We have demonstrated a novel and green approach for the synthesis of 2-substituted benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were synthesized using Amberlite IR-120 resin under microwave irradiation. The catalytic role and reusability of the resin was well established here. 2-Substituted benzothiazole analogues (3a –l ) were also tested against several bacterial strains ( Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella ) and cancer cell lines (MCF-7 and HeLa). The stability of compound 2-phenyl benzothiazole (3a ) and 2-pyridin-2-yl-benzothiazole (3k ) in GSH (0.01 mM dissolved in DMSO) was measured by UV–Vis spectroscopy. Compound3k also shows remarkable fluorescence in MeOH.