Modulation of C-reactive protein and plasma omega-6 fatty acid levels by phospholipase A2 gene polymorphisms following a 6-week supplementation with fish oil. (December 2015)

• Record Type: Journal Article
• Authors: Tremblay, B.L.; Rudkowska, I.; Couture, P.; Lemieux, S.; Julien, P.; Vohl, M.C.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 102/103(2015:Nov.)
• Page Start: 37
• Page End: 45
• Publication Date: 2015-12
• Subjects: (EPA) eicosapentaenoic acid -- (DHA) docosahexaenoic acid -- (AA) arachidonic acid -- (CRP) C-reactive protein -- (PLA2) phospholipase A2 -- (SNP) single nucleotide polymorphism -- (Δ total n-6 FAs) changes in total n-6 FAs -- (Δ CRP) changes in plasma CRP levels -- (HWE) Hardy–Weinberg equilibrium.; Gene-diet interaction -- Phospholipase A2 -- C-reactive protein -- Omega-6 fatty acid -- Omega-3 fatty acid -- Inflammation; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2015.10.002
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: This clinical trial investigated the impact of a six-week supplementation with fish oil and single nucleotide polymorphisms (SNPs) in PLA 2 G 4 A and PLA 2 G 6 genes on total omega-6 fatty acid (n-6 FA) levels in plasma phospholipids (PL) and plasma C-reactive protein (CRP) levels in 191 subjects. Interaction effects between SNPs and supplementation modulated total n-6 FAs and CRP levels in both men and women. Associations between SNPs and total n-6 FA levels and between SNPs and CRP levels were identified in men, independently of supplementation. Supplementation decreased total n-6 FAs without affecting plasma CRP levels. Changes in CRP levels correlated positively with changes in total n-6 FAs in men ( r =0.25 p =0.01), but not in women. In conclusion, total n-6 FA levels in plasma PL and plasma CRP levels are modulated by SNPs within PLA 2 G 4 A and PLA 2 G 6 genes alone or in combination with fish oil supplementation.