Lifestyle modifications supported by regional health nurses lowered insulin resistance, oxidative stress and central blood pressure in subjects with metabolic syndrome. Issue 6 (November 2015)

• Record Type: Journal Article
• Authors: Ohno, Yoichi; Miyazaki, Takashi; Sato, Makiko; Araki, Ryuichiro; Takahashi, Sachiko; Takenaka, Tsuneo; Suzuki, Hiromichi; Shibazaki, Satomi
• Is Part Of: Obesity research & clinical practice. Volume 9:Issue 6(2015:Nov./Dec.)
• Page Start: 584
• Page End: 591
• Publication Date: 2015-11
• Subjects: Lifestyle modifications -- Metabolic syndrome -- Insulin resistance -- Oxidative stress -- Blood pressure; Obesity -- Research -- Periodicals; Obesity -- Treatment -- Periodicals; Obesity -- Periodicals; Obésité -- Recherche -- Périodiques; Obésité -- Traitement -- Périodiques; Obesity -- Research; Obesity -- Treatment; Electronic journals; Periodicals; 616.398
• DOI: 10.1016/j.orcp.2015.03.003
• Languages: English
• ISSNs: 1871-403X

Abstract

Summary: Background: This study was attempted to investigate whether lifestyle modifications supported by regional health nurses should improve cardio-metabolic factors—including adipocytokines, oxidative stress, and arterial stiffness—in subjects with metabolic syndrome. Methods: Thirty-six subjects with metabolic syndrome were enrolled, 28 of whom completed the 6-month lifestyle modifications (male:female = 19:9). Blood and urine test results were examined in relation to metabolic factors before and after 6-month nutritional and physical activity modifications. In addition, oral glucose tolerance tests were performed and arterial stiffness was measured by brachial-ankle pulse wave velocity and radial augmentation index before and after them. Results: Six-month lifestyle modifications significantly reduced body weight, homeostasis model assessment index, and low-density lipoprotein cholesterol (LDL-C). They significantly attenuated oxidative stress measured by the urinary 8-hydroxy-2-deoxyguanosine/creatinine ratio. They also lowered brachial and central systolic blood pressure. They tended to decrease waist circumferences and the levels of C-reactive protein. However they did not significantly change the levels of adipocytokines, including tumour necrosis factor, soluble tumour necrosis factor receptors, and interleukin 6, or arterial stiffness measured by brachial-ankle pulse wave velocity and radial augmentation index. Conclusions: Six-month lifestyle modifications supported by regional health nurses lowered body weight, insulin resistance, LDL-C, oxidative stress, and peripheral and central blood pressure in subjects with metabolic syndrome.