Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice. (23rd October 2015) - Palladino, Claudia
Abstract : Maraviroc (MVC) is not approved for HIV-1-infected paediatric patients. This is the first assessment of the use of MVC-based salvage therapy in vertically HIV-1-infected paediatric patients in clinical settings. The results suggest that MVC-based salvage therapy is useful in children and adolescents with extensive resistance profile leading to maintained virological suppression in up to 88% of the patients with CCR5-tropic virus. The likelihood of treatment success might increase when MVC is combined with other active drugs. Abstract : Supplemental Digital Content is available in the text