Vascularisation of the central nervous system. (November 2015)

• Record Type: Journal Article
• Authors: Tata, Mathew; Ruhrberg, Christiana; Fantin, Alessandro
• Is Part Of: Mechanisms of development. Volume 138 Part 1(2015)
• Page Start: 26
• Page End: 36
• Publication Date: 2015-11
• Subjects: VEGF -- Semaphorin -- Neuropilin -- GPCR -- WNT; Developmental biology -- Periodicals; Molecular biology -- Periodicals; Developmental Biology -- Periodicals; Molecular Biology -- Periodicals; Biologie du développement -- Périodiques; Biologie moléculaire -- Périodiques; Developmental biology; Molecular biology; Periodicals; Electronic journals; 571.8
• DOI: 10.1016/j.mod.2015.07.001
• Languages: English
• ISSNs: 0925-4773

Abstract

Abstract: The developing central nervous system (CNS) is vascularised through the angiogenic invasion of blood vessels from a perineural vascular plexus, followed by continued sprouting and remodelling until a hierarchical vascular network is formed. Remarkably, vascularisation occurs without perturbing the intricate architecture of the neurogenic niches or the emerging neural networks. We discuss the mouse hindbrain, forebrain and retina as widely used models to study developmental angiogenesis in the mammalian CNS and provide an overview of key cellular and molecular mechanisms regulating the vascularisation of these organs. Graphical abstract: Highlights: CNS vascularisation is initiated during embryonic development. CNS vascularisation is studied in the mouse forebrain, hindbrain and retina models. Neuroglial cells interact with endothelial cells to promote angiogenesis. Neuroglial cells produce growth factors and matrix cues to pattern vessels.