A convenient one-pot synthesis of ketone cyanohydrin esters in aqueous media. Issue 52 (30th December 2015)

• Record Type: Journal Article
• Authors: Wet-osot, Sirawit; Pattarawarapan, Mookda; Phakhodee, Wong
• Is Part Of: Tetrahedron letters. Volume 56:Issue 52(2015)
• Page Start: 7172
• Page End: 7175
• Publication Date: 2015-12-30
• Subjects: N-Acylbenzotriazoles -- Cyanohydrin -- Ketones -- Aqueous -- Phase transfer catalyst; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.11.038
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A convenient one-pot, two-step procedure for the synthesis of ketone cyanohydrin esters in aqueous media is reported using N -acylbenzotriazoles as the acylating agents. In saturated aqueous sodium bicarbonate containing a catalytic amount of tetrabutylammonium bromide, the reaction of ketones with potassium cyanide and N -acylbenzotriazoles proceeded readily at room temperature to provide the corresponding O -acyl cyanohydrin derivatives in good to excellent yields.