Biomarkers for personalized medicine in GI cancers. (November 2015)

• Record Type: Journal Article
• Authors: Zhang, Shuang Yin; Zhang, Shuang Qin; Nagaraju, Ganji Purnachandra; El-Rayes, Bassel F.
• Is Part Of: Molecular aspects of medicine. Volume 45(2015)
• Page Start: 14
• Page End: 27
• Publication Date: 2015-11
• Subjects: Biomarkers -- Personalized medicine -- Gastrointestinal malignancy -- Gastric cancer -- Pancreatic cancer -- Colorectal cancer; Pathology, Molecular -- Periodicals; Medicine -- Periodicals; Biochemistry -- Periodicals; Medicine -- Periodicals; Molecular Biology -- Periodicals; Pathologie moléculaire -- Périodiques; Médecine -- Périodiques; Electronic journals; 612.015
• DOI: 10.1016/j.mam.2015.06.002
• Languages: English
• ISSNs: 0098-2997

Abstract

Abstract: Gastrointestinal malignancies are a major health care challenge due to the high incidence and overall poor outcome. A biomarker is a molecular characteristic of a tumor that may be utilized in the initial risk assessment and the subsequent management of the patient. This review focuses on the most pertinent prognostic and predictive biomarkers used in the clinical management of gastric, pancreas, and colon cancer. The available assays, limitations and clinical use for each biomarker are reviewed. The clinical trials evaluating novel biomarkers in GI cancers are discussed.