Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganisms. (December 2015)

• Record Type: Journal Article
• Authors: Brandt, Kristian K.; Amézquita, Alejandro; Backhaus, Thomas; Boxall, Alistair; Coors, Anja; Heberer, Thomas; Lawrence, John R.; Lazorchak, James; Schönfeld, Jens; Snape, Jason R.; Zhu, Yong-Guan; Topp, Edward
• Is Part Of: Environment international. Volume 85(2015:Dec.)
• Page Start: 189
• Page End: 205
• Publication Date: 2015-12
• Subjects: Antimicrobials -- Ecosystem services -- Ecotoxicology -- Environmental risk assessment -- Microbial ecology -- Pharmaceuticals; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2015.09.013
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Antibiotics play a pivotal role in the management of infectious disease in humans, companion animals, livestock, and aquaculture operations at a global scale. Antibiotics are produced, consumed, and released into the environment at an unprecedented scale causing concern that the presence of antibiotic residues may adversely impact aquatic and terrestrial ecosystems. Here we critically review the ecotoxicological assessment of antibiotics as related to environmental risk assessment (ERA). We initially discuss the need for more specific protection goals based on the ecosystem service concept, and suggest that the ERA of antibiotics, through the application of a mode of toxic action approach, should make more use of ecotoxicological endpoints targeting microorganisms (especially bacteria) and microbial communities. Key ecosystem services provided by microorganisms and associated ecosystem service-providing units (e.g. taxa or functional groups) are identified. Approaches currently available for elucidating ecotoxicological effects on microorganisms are reviewed in detail and we conclude that microbial community-based tests should be used to complement single-species tests to offer more targeted protection of key ecosystem services. Specifically, we propose that ecotoxicological tests should not only assess microbial community function, but also microbial diversity ('species' richness) and antibiotic susceptibility. Promising areas for future basic and applied research of relevance to ERA are highlighted throughout the text. In this regard, the most fundamental knowledge gaps probably relate to our rudimentary understanding of the ecological roles of antibiotics in nature and possible adverse effects of environmental pollution with sub-inhibitory levels of antibiotics. Highlights: Ecosystem protection goals should be based on the ecosystem service concept. Ecotoxicological endpoints related to microbial ecosystem services are identified. Mode of toxic action predicts that antibiotics will primarily affect bacteria. Improved approaches for toxicity testing of bacterial communities are discussed. Sub-inhibitory concentrations of antibiotics may compromise ecosystem services.