Tragacanth gum-based nanogel as a superparamagnetic molecularly imprinted polymer for quercetin recognition and controlled release. (20th January 2016)

• Record Type: Journal Article
• Authors: Hemmati, Khadijeh; Masoumi, Arameh; Ghaemy, Mousa
• Is Part Of: Carbohydrate polymers. Volume 136(2016)
• Page Start: 630
• Page End: 640
• Publication Date: 2016-01-20
• Subjects: Magnetic molecularly imprinted polymer -- Quercetin -- Tragacanth gum -- Vinyl imidazole -- Drug delivery -- Recognition and selective adsorption; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.09.006
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A highly selective magnetic molecularly imprinted polymer (MMIP) was synthesized. MMIP is composed of Tragacanth gum, (Fe3 O4 /SiO2 ), and poly(N-vinyl imidazole). The recognition and selectivity of MMIP and MNIP for template quercetin were tested. The adsorption followed Langmuir model with the maximum capacity of 175.43 mg g −1 . MMIP was evaluated as a drug delivery device by performing in vitro release study. Abstract: A highly selective magnetic molecularly imprinted polymer (MMIP) with core–shell structure has been synthesized by a sol–gel process composed of Tragacanth Gum (TG) crosslinker, Fe3 O4 /SiO2 nanoparticles, and N-vinyl imidazole(VI) functional monomer in the presence of template Quercetin (QC). Different techniques including scanning electron microscopy (SEM), SEM–energy dispersive spectroscopy (SEM–EDS), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) were used to verify the successful synthesis of MIP on the surface of Fe3 O4 /SiO2 nanoparticles. The swelling behavior of MMIP, its recognition and selectivity for QC and structural analog, Catechin (CT), were tested and compared with magnetic non imprinted polymer (MNIP). MMIP adsorbs the template drug quickly and equilibrium could be reached in 2 h. The mechanism for adsorption was found to follow the Langmuir model with the maximum capacity of 175.43 mg g −1 . The MMIP indicated excellent recognition and binding affinity toward QC, selectivity factor ( ɛ ) relative to CT was 2.16. Finally, the MMIP was evaluated as a drug delivery device by performing in vitro release studies in PBS.