Gray matter volume alterations in first-episode drug-naïve patients with deficit and nondeficit schizophrenia. Issue 2 (30th November 2015)

• Record Type: Journal Article
• Authors: Lei, Wei; Deng, Wei; Li, Mingli; He, Zongling; Han, Yuanyuan; Huang, Chaohua; Ma, Xiaohong; Wang, Qiang; Guo, Wanjun; Li, Yinfei; Jiang, Lijun; Gong, Qiyong; Hu, Xun; Zhang, Nanyin; Li, Tao
• Is Part Of: Psychiatry research. Volume 234:Issue 2(2015)
• Page Start: 219
• Page End: 226
• Publication Date: 2015-11-30
• Subjects: Deficit Schizophrenia -- Gray matter volume -- Voxel-based morphometry; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2015.09.015
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Different patterns of gray matter volume (GMV) abnormalities have been reported between chronic patients with deficit schizophrenia (DS), relative to nondeficit schizophrenia (NDS) patients. However, it is not clear whether these differences are characteristic to the pathophysiology of DS or due to the effects of medications or illness durations. To address this issue, GMV in 88 first-episode, drug-naive patients with schizophrenia (44 DS and 44 NDS), 67 of their first-degree relatives and 84 healthy controls were assessed using voxel- based morphometry (VBM) and compared between groups. Correlations between GMV and clinical symptoms in patients were also assessed. Compared to controls, DS patients displayed more severe GMV reduction in the cerebellar culmen than NDS patients. GMV reduction in culmen was also observed in the first-degree relatives of DS (but not NDS) patients, suggesting possible different genetic risk in DS and NDS. The left insula was significantly smaller in DS patients than both NDS patients and controls, and smaller GMV of this region was associated with more severe negative symptoms in patients. Our results collectively indicate that DS might represent a distinct subtype of schizophrenia from NDS and the GMV change in left insula may be a morphological signature of DS. Highlights: We examined gray matter volume changes in DS and NDS patients and their relatives. DS patients have less gray matter volume in left insula than NDS patients. Gray matter volume in left insula is associated with negative symptoms. Both DS patients and relatives have smaller cerebellar culmen than healthy controls. Gray matter change in left insula could be the biological marker of DS.