Canine intracranial meningiomas: Immunohistochemical evaluation of tissue factor, fibrin/fibrinogen and D-dimers. Issue 3 (December 2015)

• Record Type: Journal Article
• Authors: Font, Cristina; de la Fuente, Cristian; Pumarola, Martí; Blasco, Ester; Fernández, Francisco; Viu, Judit; Añor, Sònia
• Is Part Of: Veterinary journal. Volume 206:Issue 3(2015)
• Page Start: 426
• Page End: 428
• Publication Date: 2015-12
• Subjects: Brain -- Neoplasia -- Tissue factor -- Coagulation -- Fibrinolysis -- Immunohistochemistry -- Dog; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.07.008
• Languages: English
• ISSNs: 1090-0233

Abstract

Highlights: The haemostatic system plays a role in angiogenesis, tumour growth and metastasis. Tissue factor (TF) is expressed in canine meningiomas. There is intratumoural coagulation and fibrinolytic activity in canine meningiomas. The haemostatic system is involved in canine meningioma pathobiology. Abstract: The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.