Highly chemoselective hydrogenation of active benzaldehydes to benzyl alcohols catalyzed by bimetallic nanoparticles. Issue 46 (18th November 2015)

• Record Type: Journal Article
• Authors: Liu, Chulong; Bao, Hailin; Wang, Dingsheng; Wang, Xinyan; Li, Yadong; Hu, Yuefei
• Is Part Of: Tetrahedron letters. Volume 56:Issue 46(2015)
• Page Start: 6460
• Page End: 6462
• Publication Date: 2015-11-18
• Subjects: Chemoselectivity -- Catalytic hydrogenation -- Active benzaldehydes -- Benzyl alcohols -- Bimetallic nanoparticles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.09.154
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: By using novel Pd/Ni bimetallic nanoparticles as a catalyst, the active benzaldehydes were hydrogenated to the corresponding benzyl alcohols as unique products in practical quantitative yields. The undesired catalytic hydrogenolysis of the benzyl alcohol was inhibited completely. By using this hydrogenation as a key step, the total synthesis of the natural product gastrodin was achieved with less total steps and a higher total yield.