Maternal Serum 25‐Hydroxyvitamin D Concentrations during Pregnancy and Infant Birthweight for Gestational Age: a Three‐Cohort Study. Issue 2 (17th November 2015)

• Record Type: Journal Article
• Authors: Tian, Yan; Holzman, Claudia; Siega‐Riz, Anna M.; Williams, Michelle A.; Dole, Nancy; Enquobahrie, Daniel A.; Ferre, Cynthia D.
• Is Part Of: Paediatric and perinatal epidemiology. Volume 30:Issue 2(2016:Mar.)
• Page Start: 124
• Page End: 133
• Publication Date: 2015-11-17
• Subjects: birthweight for gestational age -- race/ethnicity -- pregnancy -- sex difference -- 25‐hydroxyvitamin D; Pediatrics -- Periodicals; Perinatology -- Periodicals; Pediatric epidemiology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; 618.92
• DOI: 10.1111/ppe.12262
• Languages: English
• ISSNs: 0269-5022

Abstract

Abstract: Background: In response to inconsistent findings, we investigated associations between maternal serum 25‐hydroxyvitamin D [25(OH)D] concentrations and infant birthweight for gestational age (BW/GA), including potential effect modification by maternal race/ethnicity and infant sex. Methods: Data from 2558 pregnant women were combined in a nested case–control study (preterm and term) sampled from three cohorts: the Omega study, the Pregnancy, Infection and Nutrition study, and the Pregnancy Outcomes and Community Health study. Maternal 25(OH)D concentrations were sampled at 4 to 29 weeks gestation (80% 14–26 weeks). BW/GA was modelled as sex and gestational age‐specific birthweight z‐scores. General linear regression models (adjusting for age, education, parity, pre‐pregnancy body mass index, season at blood draw, and smoking) assessed 25(OH)D concentrations in relation to BW/GA. Results: Among non‐Hispanic Black women, the positive association between 25(OH)D concentrations and BW/GA was of similar magnitude in pregnancies with female or male infants [beta (β) = 0.015, standard error (SE) = 0.007, P = 0.025; β = 0.018, SE = 0.006, P = 0.003, respectively]. Among non‐Hispanic White women, 25(OH)D‐BW/GA association was observed only with male infants, and the effect size was lower (β = 0.008, SE = 0.003, P = 0.02). Conclusions: Maternal serum concentrations of 25(OH)D in early and mid‐pregnancy were positively associated with BW/GA among non‐Hispanic Black male and female infants and non‐Hispanic White male infants. Effect modification by race/ethnicity may be due, in part, to overall lower concentrations of 25(OH)D in non‐Hispanic Blacks. Reasons for effect modification by infant sex remain unclear.