Genomic approach to selective vulnerability of the hippocampus in brain ischemia–hypoxia. (19th November 2015)

• Record Type: Journal Article
• Authors: Schmidt-Kastner, Rainald
• Is Part Of: Neuroscience. Volume 309(2015)
• Page Start: 259
• Page End: 279
• Publication Date: 2015-11-19
• Subjects: ABA Allen Brain Atlas -- ARNT aryl hydrocarbon receptor nuclear translocator -- BDNF brain-derived neurotrophic factor -- CBF cerebral blood flow -- CSF cerebrospinal fluid -- ER Endoplasmic Reticulum -- ES Enrichment Score -- HIF Hypoxia Inducible Factor -- HSPs heat shock proteins -- IEGs immediate early genes -- IHR ischemia–hypoxia response -- OGD oxygen-glucose-deprivation -- ROS reactive oxygen species -- UPR unfolded protein response; ischemia -- hypoxia -- hippocampus -- selective vulnerability -- gene expression; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2015.08.034
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Selective vulnerability of the hippocampus is related to neuronal factors. Global brain ischemia damages neurons in CA1. Genomic studies provide maps for gene expression in the hippocampus. Genes expressed in CA1 are related to the ischemia response. Abstract: Transient global ischemia selectively damages neurons in specific brain areas. A reproducible pattern of selective vulnerability is observed in the dorsal hippocampus of rodents where ischemic damage typically affects neurons in the CA1 area while sparing neurons in CA3 and granule cells. The "neuronal factors" underlying the differential vulnerability of CA1 versus CA3 have been of great interest. This review first provides on overview of the histological pattern of ischemic–hypoxic damage, the phenomenon of delayed neuronal death, the necrosis–apoptosis discussion, and multiple molecular mechanisms studied in the hippocampus. Subsequently, genomic studies of basal gene expression in CA1 and CA3 are summarized and changes in gene expression in response to global brain ischemia are surveyed. A formal analysis is presented for the overlap between genes expressed under basal conditions in the hippocampus and genes responding to ischemia–hypoxia in general. A possible role of the elusive vascular factors in selective vulnerability is reviewed, and a gene set for angiogenesis is then shown to be enriched in the CA3 gene set. A survey of selective vulnerability in the human hippocampus in relation to genomic studies in ischemia–hypoxia is presented, and neurodegeneration genes with high expression in CA1 are highlighted (e.g. WFS1). It is concluded that neuronal factors dominate the selective vulnerability of CA1 but that vascular factors also deserve more systematic studies.