Hippocampal plasticity during the progression of Alzheimer's disease. (19th November 2015)

• Record Type: Journal Article
• Authors: Mufson, E.J.; Mahady, L.; Waters, D.; Counts, S.E.; Perez, S.E.; DeKosky, S.T.; Ginsberg, S.D.; Ikonomovic, M.D.; Scheff, S.W.; Binder, L.I.
• Is Part Of: Neuroscience. Volume 309(2015)
• Page Start: 51
• Page End: 67
• Publication Date: 2015-11-19
• Subjects: AD Alzheimer's disease -- aMCI amnestic mild cognitive impairment -- APP amyloid-beta precursor protein -- Aβ amyloid-beta -- CBF cholinergic basal forebrain -- ChAT choline acetyltransferease -- DG dentate gyrus -- JNK c-Jun N-terminal protein kinase -- MCI mild cognitive impairment -- MMSE Mini-Mental State Exam -- MTL medial temporal lobe -- NCI no cognitive impairment -- NFT neurofibrillary tangle -- NGF nerve growth factor -- NMDA N-methyl-d-aspartate -- p75NTR p75 neurotrophin receptor -- SPs senile plaques; hippocampus -- Alzheimer's disease -- neurotrophins -- mild cognitive impairment -- plasticity -- degeneration; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2015.03.006
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Hippocampal plasticity in AD. Molecular plasticity in AD. Hippocampal vulnerability in AD. Abstract: Neuroplasticity involves molecular and structural changes in central nervous system (CNS) throughout life. The concept of neural organization allows for remodeling as a compensatory mechanism to the early pathobiology of Alzheimer's disease (AD) in an attempt to maintain brain function and cognition during the onset of dementia. The hippocampus, a crucial component of the medial temporal lobe memory circuit, is affected early in AD and displays synaptic and intraneuronal molecular remodeling against a pathological background of extracellular amyloid-beta (Aβ) deposition and intracellular neurofibrillary tangle (NFT) formation in the early stages of AD. Here we discuss human clinical pathological findings supporting the concept that the hippocampus is capable of neural plasticity during mild cognitive impairment (MCI), a prodromal stage of AD and early stage AD.