A phase II exercise randomized controlled trial for patients with acute myeloid leukemia undergoing induction chemotherapy. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Alibhai, S.M.H.; Durbano, S.; Breunis, H.; Brandwein, J.M.; Timilshina, N.; Tomlinson, G.A.; Oh, P.I.; Culos-Reed, S.N.
• Is Part Of: Leukemia research. Volume 39:Issue 11(2015:Nov.)
• Page Start: 1178
• Page End: 1186
• Publication Date: 2015-11
• Subjects: Acute myeloid leukemia -- Chemotherapy -- Exercise -- Quality of life -- Cancer-related fatigue; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.08.012
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: Induction chemotherapy (IC) for AML is associated with physical deconditioning. We examined the efficacy of supervised exercise during IC on quality of life, fatigue, and fitness. Results demonstrate that supervised exercise in this population is feasible and safe. Preliminary efficacy for improving fatigue, fitness, QOL, and treatment tolerability were noted. Abstract: Curative treatment for acute myeloid leukemia (AML) involves induction chemotherapy (IC) which is associated with bed rest and toxicities, leading to worsening quality of life (QOL), fatigue, and fitness. Exercise during IC may ameliorate declines but has not been rigorously tested. We examined the efficacy of supervised exercise during IC on QOL, fatigue, and fitness. Eighty-three inpatients age 18–80 scheduled to receive IC for newly diagnosed or relapsed AML were randomized 2:1 (exercise intervention:control group). Study measures were completed at baseline, post-IC, and following the first cycle of consolidation. The intervention consisted of a supervised mixed-modality, moderate-intensity exercise program (4–5 days per week, 30–60 min per session) throughout admission. Recruitment was good (56%), retention excellent (96%), and adherence was 54%. Global QOL improved similarly in both groups from baseline to post-IC (between-group difference 3.0 points, p = 0.62). Fatigue improved in the exercise group from baseline to post-IC (potentially clinically important between-group difference of 3.6 points, p = 0.23). Aerobic fitness, lower body strength, and grip strength improved in the exercise group (between-group differences p = 0.005, p < 0.001, p = 0.03, respectively). Supervised exercise for patients with AML undergoing IC is feasible, safe, and appears effective at improving fitness and possibly fatigue. A larger trial is warranted.