A 3-day high-fat/low-carbohydrate diet does not alter exercise-induced growth hormone response in healthy males. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Sasaki, Hiroto; Ishibashi, Aya; Tsuchiya, Yoshihumi; Shimura, Nobuhiro; Kurihara, Toshiyuki; Ebi, Kumiko; Goto, Kazushige
• Is Part Of: Growth hormone & IGF research. Volume 25:Issue 6(2015:Dec.)
• Page Start: 304
• Page End: 311
• Publication Date: 2015-12
• Subjects: HF-LC high-fat/low-carbohydrate diet -- LF-HC low-fat/high-carbohydrate diet -- GH growth hormone -- V˙O2max maximal oxygen uptake -- IMCL intramyocellular lipid -- FFA free fatty acid -- BMI body mass index -- SE standard error -- BDHQ brief type self-administered diet history questionnaire -- V˙O2 oxygen uptake -- HR heart rate -- VL vastus lateralis -- SOL soleus -- TA tibialis anterior -- MR magnetic resonance -- HDL high density lipoprotein -- LDL low density lipoprotein -- TG triglycerides -- IGF-I insulin like growth factor I -- IL-6 interleukin-6 -- CVs coefficient of variation -- V˙CO2 carbon dioxide production -- RER respiratory exchange ratio -- RPE rating of perceived exertion -- ANOVA analysis of variance -- AUC area under the curve -- HOMA-IR the homeostatic model assessment of insulin resistance; High-fat diet -- Growth hormone -- Exercise -- Intramyocellular lipid content -- Fat metabolism -- Healthy men; Growth regulators -- Periodicals; Growth -- Regulation -- Periodicals; Somatomedin -- Periodicals; Somatomedins -- Periodicals; Growth Hormone -- Periodicals; Growth Substances -- Periodicals; Croissance -- Régulation -- Périodiques; Croissance -- Régulateurs -- Périodiques; Somatotrophine -- Périodiques; Somatomédine -- Périodiques; Growth -- Regulation; Growth regulators; Electronic journals; Periodicals; Electronic journals; 612.4
• DOI: 10.1016/j.ghir.2015.07.005
• Languages: English
• ISSNs: 1096-6374

Abstract

Abstract: Objective: The purpose of the present study was to examine the effects of 3 days isoenergetic high-fat/low-carbohydrate diet (HF-LC) relative to low-fat/high-carbohydrate diet (LF-HC) on the exercise-induced growth hormone (GH) response in healthy male subjects. Design: Ten healthy young males participated in this study. Each subject consumed the HF-LC (18 ± 1% protein, 61 ± 2% fat, 21 ± 1% carbohydrate, 2720 kcal per day) for 3 consecutive days after consuming the LF-HC (18 ± 1% protein, 20 ± 1% fat, 62 ± 1% carbohydrate, 2755 kcal per day) for 3 consecutive days. After each dietary intervention period, the hormonal and metabolic responses to an acute exercise (30 min of continuous pedaling at 60% of V ˙ O2max ) were compared. The intramyocellular lipid (IMCL) contents in the vastus lateralis, soleus, and tibialis anterior were evaluated by proton magnetic resonance spectroscopy. Results: Serum GH concentrations increased significantly during the exercise after both the HF-LC and LF-HC periods ( P < 0.05). However, the exercise-induced GH response was not significantly different between the two periods. Fat utilization and lipolytic responses during the exercise were enhanced significantly after the HF-LC period compared with the LF-HC period. IMCL content did not differ significantly in any portion of muscle after the dietary interventions. Conclusions: We could not show that short-term HF-LC consumption changed significantly exercise-induced GH response or IMCL content in healthy young males. Highlights: It could not be confirmed that a 3-day high-fat/low-carbohydrate diet altered significantly exercise-induced growth hormone response despite of increased FFA level. Exercise-induced lipolytic and fat-oxidative responses were enhanced by consumption of high-fat/low-carbohydrate diet for three days. Intramyocellular lipid contents did not change after short-term consuming high-fat/low-carbohydrate diet.