How do changes at the cell level affect the mechanical properties of epithelial monolayers?. Issue 45 (21st September 2015)

• Record Type: Journal Article
• Authors: Xu, Guang-Kui; Liu, Yang; Li, Bo
• Is Part Of: Soft matter. Volume 11:Issue 45(2015)
• Page Start: 8782
• Page End: 8788
• Publication Date: 2015-09-21
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/c5sm01966d
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : We investigated the mechanical behaviors of an epithelial monolayer and cell configurations within the monolayer during stretch. The epithelial monolayer exhibited elastic and plastic properties, originating from the geometric extension of cells and the division of cells, respectively. Abstract : Epithelial monolayers play a vital role in gastrulation, tumor metastasis and wound healing, and protect the tissue from pathogens. During these processes, the monolayers sense, generate, and exert mechanical forces to perform their biological functions, but their mechanical properties are rarely known. Here, we use the vertex dynamics models to investigate the mechanical behaviors of an epithelial monolayer and the configurations of the cells within the monolayer during stretch. It was found that the epithelial monolayer exhibited elastic and plastic properties, due to the geometric extension of cells and cell division, respectively. Moreover, the elasticity of monolayers was increased by enhancing the cell adhesion or by reducing the active contractility of actin-myosin rings. This study furthers our understanding of the relationship between the mechanical properties of individual cells and of their monolayers, and may shed light on linking cell behavior to the patterning and morphogenesis of tissues.