Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine–lobeline hybrid analogues. Issue 117 (11th November 2015)

• Record Type: Journal Article
• Authors: Drège, E.; Oko, J.; Venot, P.-E.; Gigant, N.; Joseph, D.
• Is Part Of: RSC advances. Volume 5:Issue 117(2015)
• Page Start: 96720
• Page End: 96724
• Publication Date: 2015-11-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra20930g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Step-economical access to nicotinic acetylcholine receptor ligands hybrids through an efficient telescoped cross-metathesis/cyclizing aza-Michael addition involving N-heteroaromatic olefinic derivatives. Abstract : A series of 2, 5-disubstituted pyrrolidines was synthesized through an efficient telescoped cross-metathesis/cyclizing aza-Michael addition involving N-heteroaromatic olefinic derivatives. This synthetic route was applied to the preparation of original nicotine–lobeline, nicotine–pelletierine and lobeline–nicotine–epibatidine hybrids.