A greener procedure for the synthesis of α-ureidophosphonates under ultrasound irradiation. An X-ray crystallographic study. Issue 121 (20th November 2015)

• Record Type: Journal Article
• Authors: Bouzina, Abdeslem; Berredjem, Malika; Bouacida, Sofiane; Merazig, Hocine; Aouf, Nour-eddine
• Is Part Of: RSC advances. Volume 5:Issue 121(2015)
• Page Start: 99775
• Page End: 99780
• Publication Date: 2015-11-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19886k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The synthesis of α-ureidophosphonates via a one-pot three-component reaction using ultrasonic irradiation under solvent- and catalyst-free conditions at 75° is developed. The products were obtained in excellent yields within short reaction times. Abstract : An efficient, eco-sustainable and greener procedure for the synthesis of α-ureidophosphonates via a one-pot three-component reaction of aldehydes, urea/thiourea and triethylphosphite or diethylphosphite using ultrasonic irradiation under solvent- and catalyst-free conditions at 75°, is developed. The desired products were obtained in excellent yields within short reaction times (15–30 min). Crystals of diethyl[α-ureido-(4-methylphenyl)]methyl phosphonate suitable for X-ray study have been obtained after recrystallization in a mixture of diethyl ether and n -hexane. The detailed analysis of the molecular and crystal structure is presented.