Continuous in situ electrogenaration of a 2-pyrrolidone anion in a microreactor: application to highly efficient monoalkylation of methyl phenylacetate. Issue 117 (11th November 2015)

• Record Type: Journal Article
• Authors: Matsumura, Yoshimasa; Kakizaki, Yoshinobu; Tateno, Hiroyuki; Kashiwagi, Tsuneo; Yamaji, Yoshiyuki; Atobe, Mahito
• Is Part Of: RSC advances. Volume 5:Issue 117(2015)
• Page Start: 96851
• Page End: 96854
• Publication Date: 2015-11-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19286b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : We have successfully demonstrated effective generation of an electrogenerated base (EGB) such as the 2-pyrrolidone anion and its rapid use for the following alkylation reaction in a flow microreactor system without the need for severe reaction conditions. Abstract : We have successfully demonstrated effective generation of an electrogenerated base (EGB) such as the 2-pyrrolidone anion and its rapid use for the following alkylation reaction in a flow microreactor system without the need for severe reaction conditions. The key feature of the method is effective and selective preparation of monoalkylated products.