Copper(i)–triazole dimer formation and rate acceleration in in-source click reaction. Issue 116 (11th November 2015)

• Record Type: Journal Article
• Authors: Qiu, Ran; Luo, Hai
• Is Part Of: RSC advances. Volume 5:Issue 116(2015)
• Page Start: 96213
• Page End: 96221
• Publication Date: 2015-11-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19855k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Click and beyond click. A copper(i ) triazole dimer was discovered in in-source click reaction, which indicated significant rate acceleration effect. Abstract : Besides analytical applications, ambient mass spectrometry (MS) is also a special platform to execute various chemical reactions. Chemistry in laser desorption-based, ambient MS ion sources has unique features. Previously, laser-ablated copper(i ) ions were used to catalyze in-source click reactions. The advances of such in-source reaction are presented here. First, the encounter and structure elucidation of a copper(i ) triazole dimer are demonstrated. Then, based on the quick appearance of such dimer in the HALDI-MS spectrum, the rate acceleration effect is studied. Last, the crystalized dimer is used to catalyze the in-flask click reaction, and confirms the proposed "di-nuclear mechanism" of the click reaction. This work is another example of how ambient in-source chemistry having unique features compares with traditional in-flask chemistry, and also shows that new insightful information can be obtained from results of ambient in-source reactions.