Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety. Issue 111 (27th October 2015)

• Record Type: Journal Article
• Authors: Wang, Shuai-Yu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiang-Qian; Luo, Jiao; Wang, Bao-Cheng; Zhang, Ren-Shuai; Xu, Qi; Shi, Da-Yong
• Is Part Of: RSC advances. Volume 5:Issue 111(2015)
• Page Start: 91795
• Page End: 91801
• Publication Date: 2015-10-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19617e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their anticancer activities in vitro . Abstract : A series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their anticancer activities in vitro . Among them, compounds6, 7, 9, 12 and13 showed potent activities against the tested human cancer cell lines. Notably, compound6 showed significant activities against A549, Bel7402, HepG2, HCT116 and HeLa cancer cell lines, which were comparable to those of sunitinib. Further study on its mechanisms demonstrated that compound6 can be used as a potential anticancer agent for inhibiting proliferation and inducing apoptosis of HepG2 cells, along with inhibiting angiogenesis of HUVECs.