Photocatalytic direct intermolecular addition of 1, 3-dithianes. Issue 105 (13th October 2015)

• Record Type: Journal Article
• Authors: Lee, Ming; Chen, Ying-Ho; Hung, Tzu-Hang; Chang, Wen; Yan, Wei-Cheng; Leow, Dasheng
• Is Part Of: RSC advances. Volume 5:Issue 105(2015)
• Page Start: 86402
• Page End: 86406
• Publication Date: 2015-10-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra19069j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A direct intermolecular radical addition of 1, 3-dithianes to alkenes has been accomplished via visible-light mediated photocatalysis. Abstract : A direct intermolecular addition of 1, 3-dithianes to alkenes has been accomplished via visible-light mediated photocatalysis. This new process proceeds in moderate to excellent yields and eliminates the need for pre-functionalization of substrates. Electronic tuning of the 1, 3-dithiane plays a vital role in ensuring reactivity. Both aromatic and aliphatic aldehyde-derived 1, 3-dithianes are compatible. This radical umpolung strategy allows the synthesis of γ-keto-α-amino acid derivatives.