The Diagnostic Apathia Scale predicts a dose–remission relationship of T-PEMF in treatment-resistant depression. Issue 1 (2nd October 2014)

• Record Type: Journal Article
• Authors: Bech, Per; Lunde, Marianne; Lauritzen, Lise; Straasø, Birgit; Lindberg, Lone; Vinberg, Maj; Undén, Mogens; Hellström, Lone Christina; Dissing, Steen; Larsen, Erik Roj
• Is Part Of: Acta neuropsychiatrica. Volume 27:Issue 1(2015:Feb.)
• Page Start: 1
• Page End: 7
• Publication Date: 2014-10-02
• Subjects: apathy, -- depressive disorder, -- predictive value of tests, -- transcranial pulsating electromagnetic fields, -- treatment-resistant depression; Neuropsychiatry -- Periodicals; 616.89
• DOI: 10.1017/neu.2014.26
• Languages: English
• ISSNs: 0924-2708

Abstract

Abstract : Objective: The aim of this study was to evaluate the predictive validity of the apathy subsyndrome in patients with therapy-resistant depression in the dose–remission study with transcranial pulsating electromagnetic fields (T-PEMF). Methods: The apathy subsyndrome consists of the symptoms of fatigue, concentration and memory problems, lack of interests, difficulties in making decisions, and sleep problems. We evaluated 65 patients with therapy-resistant depression. In total, 34 of these patients received placebo T-PEMF in the afternoon and active T-PEMF in the morning, that is, one daily dose. The remaining 31 patients received active T-PEMF twice daily. Duration of treatment was 8 weeks in both groups. The Hamilton Depression Scale (HAM-D17 ) and the Bech-Rafaelsen Melancholia Scale (MES) were used to measure remission. We also focused on the Diagnostic Apathia Scale, which is based on a mixture of items from the MINI and the HAM-D17 /MES. Results: In patients without apathy, the remission rate after T-PEMF was 83.9% versus 58.8% in patients with apathy ( p ≤0.05). In patients without apathy receiving one active dose daily 94.4% remitted versus 50% for patients with apathy ( p ≤0.05). In patients without apathy who received two active doses 69.9% remitted versus 66.7% for patients with apathy ( p ≤0.05). Conclusion: Taking the baseline diagnosis of the apathy syndrome into consideration, we found that in patients without apathy one daily dose of T-PEMF is sufficient, but in patients with apathy two daily doses are necessary. Including the apathy syndrome as predictor in future studies would seem to be clinically relevant.