A novel heterobimetallic Ru(ii)–Gd(iii) complex-based magnetoluminescent agent for MR and luminescence imaging. Issue 117 (9th November 2015)

• Record Type: Journal Article
• Authors: Shi, Wenbo; Song, Bo; Tan, Mingqian; Ye, Zhiqiang; Yuan, Jingli
• Is Part Of: RSC advances. Volume 5:Issue 117(2015)
• Page Start: 96525
• Page End: 96531
• Publication Date: 2015-11-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra18544k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel heterobimetallic ruthenium(II)–gadolinium(III) complex, Ru–Gd, has been developed for luminescence and an vivo T 1 -weighted MR imaging agent. Abstract : A novel heterobimetallic ruthenium(ii )–gadolinium(iii ) complex, Ru–Gd, comprising a luminescent Ru(ii ) complex, [Ru(bpy)2 (phen)] 2+ (bpy: 2, 2′-bipyridine; phen: 1, 10-phenanthroline), and a Gd(iii ) complex, DOTA–Gd 3+ (DOTA: 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid), has been designed and synthesized as a magnetoluminescent dual-modal imaging agent. The heterobimetallic complexRu–Gd is water-soluble, biocompatible with low cytotoxicity, strongly luminescent with a long luminescence lifetime and a large Stokes shift, and has comparable longitudinal relaxivity r 1 (4.71 mM −1 s −1 ), which enable the complex to be suitable for luminescence bioimaging and T 1 -weighted MR imaging. UsingRu–Gd as a contrast agent, the T 1 -weighted MRI of a Kunming (KM) mouse was successfully carried out. The results demonstrated the availability and validity of our approach for the development of magnetoluminescent dual-modal imaging agents.