Iron-catalyzed regioselective direct coupling of aromatic aldehydes with coumarins leading to 3-aroyl coumarins. Issue 107 (19th October 2015)

• Record Type: Journal Article
• Authors: Yuan, Jin-Wei; Yin, Qiu-Yue; Yang, Liang-Ru; Mai, Wen-Peng; Mao, Pu; Xiao, Yong-Mei; Qu, Ling-Bo
• Is Part Of: RSC advances. Volume 5:Issue 107(2015)
• Page Start: 88258
• Page End: 88265
• Publication Date: 2015-10-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra16573c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Iron-catalyzed direct radical acylation of coumarins with aromatic aldehydes to regioselectively afford 3-aroyl coumarin derivatives in moderate yields was described. Abstract : An efficient protocol for iron-catalyzed cross-coupling of coumarins with aromatic aldehydes has been developed. The various 3-aroyl coumarins were selectively afforded in moderate yields. Some notable features of this protocol are high efficiency, wide functional group tolerance, and commercially available and cheap aromatic aldehydes and coumarins as starting materials. Furthermore, these reaction conditions were also applicable to N -methyl quinolinones, affording the corresponding 3-aroyl quinolinone derivatives in good yields.