Interaction of chitosan beads with a copper–naproxen metallodrug. Issue 109 (22nd October 2015)

• Record Type: Journal Article
• Authors: de J. Martins, Douglas; Hanif-Ur-Rehman, ; Alves Rico, Samara R.; de M. Costa, Iguatinã; Pio Santos, Andrea C.; Szszudlowski, Rachel G.; de Oliveira Silva, Denise
• Is Part Of: RSC advances. Volume 5:Issue 109(2015)
• Page Start: 90184
• Page End: 90192
• Publication Date: 2015-10-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra16878c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new hybrid material resulting from the interaction of chitosan beads with a copper–naproxen metallodrug was prepared and characterized. The Acrycoat-coated beads were investigated for release behavior in gastric/intestinal pH simulated solutions. Abstract : This manuscript reports a novel hybrid system containing a copper-drug entrapped into the chitosan biopolymer. Chitosan beads (CTb) were prepared and investigated for interaction with a copper metallodrug (CuNpx) of the naproxen (HNpx) non-steroidal anti-inflammatory drug. The loading capacity of CTb for CuNpx suggests a sponge-like behavior for copper-drug entrapping at a CuNpx concentration range from 10 −4 to 10 −2 mol L −1 . A novel CTb/CuNpx hybrid material formed by the copper-drug loaded into chitosan beads was prepared and characterized by elemental analysis, scanning electron microscopy, electronic absorption spectroscopy, FTIR spectroscopy, X-ray diffractometry and thermal analysis. The CTb/CuNpx hybrid material was coated with Acrycoat S100, and its behavior in gastric/intestinal pH simulated solutions was investigated to verify potential releasing properties. The coated beads showed a capacity to release naproxen in a sustained release manner for at least 24 h.