Localized radiation necrosis model in mouse brain using proton ion beams. (December 2015)

• Record Type: Journal Article
• Authors: Kondo, Natsuko; Sakurai, Yoshinori; Takata, Takushi; Takai, Nobuhiko; Nakagawa, Yosuke; Tanaka, Hiroki; Watanabe, Tsubasa; Kume, Kyo; Toho, Taichiro; Miyatake, Shin-ichi; Suzuki, Minoru; Masunaga, Shin-ichiro; Ono, Koji
• Is Part Of: Applied radiation and isotopes. Volume 106(2015:Dec.)
• Page Start: 242
• Page End: 246
• Publication Date: 2015-12
• Subjects: Brain radiation necrosis model -- Proton beams -- MRI -- Histology; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2015.07.032
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Brain radiation necrosis is the most serious late adverse event that occurs after 6 months following radiation therapy. Effective treatment for this irreversible brain necrosis has not been established yet. This study tries to establish brain radiation necrosis mouse model using proton or helium beam. The right cerebral hemispheres of C57BL/6J mouse brains were irradiated at doses of 40, 50, 60 Gy with charged particles. In 60 Gy group, brain necrosis that recapitulates human disease was detected after 8 months. Highlights: Brain necrosis mouse model was established. Brain necrosis was induced 8 months after single proton beam irradiation at 60 Gy. Histology of the mouse model recapitulated the human patients.