Boron containing magnetic nanoparticles for neutron capture therapy – an innovative approach for specifically targeting tumors. (December 2015)

• Record Type: Journal Article
• Authors: Tietze, Rainer; Unterweger, Harald; Dürr, Stephan; Lyer, Stefan; Canella, Lea; Kudejova, Petra; Wagner, Franz M.; Petry, Winfried; Taccardi, Nicola; Alexiou, Christoph
• Is Part Of: Applied radiation and isotopes. Volume 106(2015:Dec.)
• Page Start: 151
• Page End: 155
• Publication Date: 2015-12
• Subjects: BNCT -- Magnetic Drug Targeting -- Nanomedicine; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2015.07.028
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: The selective delivery of 10 B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted 10 B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and nanoparticles as well as varying three-dimensional arrangements have been performed. Highlights: Magnetic Drug Targeting is a possible approach to substantially improve BNCT. SPIONs did not influence the radiation dose deposition. Superior dose deposition in gel phantoms reflecting Magnetic Drug Targeting set up.