Bioabsorbable bioadhesive hydrogel comprising poly(acrylic acid) and poly(vinylpyrrolidone) for adhesion barrier and hemostatic device. (26th March 2015)

• Record Type: Journal Article
• Authors: Ito, Tomoko; Eriguchi, Masazumi; Koyama, Yoshiyuki
• Is Part Of: MRS communications. Volume 5:Number 2(2015:Jun.)
• Page Start: 291
• Page End: 295
• Publication Date: 2015-03-26
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1557/mrc.2015.14
• Languages: English
• ISSNs: 2159-6859

Abstract

Abstract: Abstract : Poly(acrylic acid) (PAA) and poly(vinylpyrrolidone) (PVP) are both highly safe synthetic polymers approved as pharmaceutical excipients. When their aqueous solutions are mixed, insoluble rigid complex is precipitated. On the other hand, if the dried PAA film was immersed in aqueous PVP solution, swollen PAA/PVP soft hydrogel was obtained. Heated drying of the gel afforded a transparent water-swellable film. The swellable PAA/PVP complex film exhibited favorable properties in medical use. If the film was put on a bleeding site, it swelled, and stuck to a hemorrhaging spot, and efficiently arrested bleeding. It could also prevent the adhesion formation by injured intestines.