Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging. Issue 44 (22nd October 2015)

• Record Type: Journal Article
• Authors: Srinivas, Ramishetti; Satterlee, Andrew; Wang, Yuhua; Zhang, Yuan; Wang, Yongjun; Huang, Leaf
• Is Part Of: Nanoscale. Volume 7:Issue 44(2015)
• Page Start: 18542
• Page End: 18551
• Publication Date: 2015-10-22
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr04509f
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Etoposide phosphate, a water-soluble anti-cancer prodrug, was successfully encapsulated together with indium in nanoparticles. We have used indium both as a carrier to deliver etoposide phosphate and as a SPECT imaging agent through incorporation of 111 In. Abstract : Etoposide phosphate (EP), a water-soluble anticancer prodrug, is widely used for treatment of many cancers. After administration it is rapidly converted to etoposide, its parent compound, which exhibits anticancer activity. Difficulty in parenteral administration necessitates the development of a suitable nanoparticle delivery system for EP. Here we have used indium both as a carrier to deliver etoposide phosphate to tumor cells and as a SPECT imaging agent through incorporation of 111 In. Etoposide phosphate was successfully encapsulated together with indium in nanoparticles, and exhibited dose dependent cytotoxicity and induction of apoptosis in cultured H460 cancer cells via G2/M cell cycle arrest. In a mouse xenograft lung cancer model, etoposide phosphate/indium nanoparticles induce tumor cell apoptosis, leading to significant enhancement of tumor growth inhibition compared to the free drug.