Organometallic rhodium(iii) and iridium(iii) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands. Issue 47 (9th November 2015)

• Record Type: Journal Article
• Authors: Pettinari, Riccardo; Marchetti, Fabio; Pettinari, Claudio; Condello, Francesca; Petrini, Agnese; Scopelliti, Rosario; Riedel, Tina; Dyson, Paul J.
• Is Part Of: Dalton transactions. Volume 44:Issue 47(2015)
• Page Start: 20523
• Page End: 20531
• Publication Date: 2015-11-09
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c5dt03037d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Rhodium(iii ) and iridium(iii ) complexes containing curcumin ligands show moderate cytotoxicity to human ovarian carcinoma cells and also to non-tumorigenic human embryonic kidney cells. Abstract : A series of half-sandwich cyclopentadienyl rhodium(iii ) and iridium(iii ) complexes of the type [Cp*M(curc/bdcurc)Cl] and [Cp*M(curc/bdcurc)(PTA)][SO3 CF3 ], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O^O-chelating ligands, and PTA = 1, 3, 5-triaza-7-phosphaadamantane, is described. The X-ray crystal structures of three of the complexes, i.e. [Cp*Rh(curc)(PTA)][SO3 CF3 ] (5 ), [Cp*Rh(bdcurc)(PTA)][SO3 CF3 ] (6 ) and [Cp*Ir(bdcurc)(PTA)][SO3 CF3 ] (8 ), confirm the expected "piano-stool" geometry. With the exception of5, the complexes are stable under pseudo-physiological conditions and are moderately cytotoxic to human ovarian carcinoma (A2780 and A2780cisR) cells and also to non-tumorigenic human embryonic kidney (HEK293) cells, but lack the cancer cell selectivity observed for related arene ruthenium(ii ) complexes.