Multi-lineage differentiation of mesenchymal stem cells – To Wnt, or not Wnt. (November 2015)

• Record Type: Journal Article
• Authors: Visweswaran, Malini; Pohl, Sebastian; Arfuso, Frank; Newsholme, Philip; Dilley, Rodney; Pervaiz, Shazib; Dharmarajan, Arun
• Is Part Of: International journal of biochemistry & cell biology. Volume 68(2015:Nov.)
• Page Start: 139
• Page End: 147
• Publication Date: 2015-11
• Subjects: Mesenchymal stem cells -- Differentiation -- Wnt -- Reactive oxygen species -- Cellular fate; ADSCs adipose tissue-derived MSCs -- APC adenomatous polyposis coli -- BIO 6-bromo-indirubin-3′-oxime -- BMP bone morphogenetic protein -- C/EBPα CCAAT/enhancer binding protein alpha -- C/EBPβ CCAAT/enhancer binding protein beta -- CaMKII calcium/calmodulin-dependent protein kinase II -- CK1α casein kinase 1 alpha -- CRD cysteine-rich domain -- CREB cAMP response element binding protein -- Dkk Dickkopfs -- Dvl Dishevelled -- DZNep 3-deazaneplanocin A -- EZH2 Enhancer of Zeste Homology 2 -- Fz Frizzled -- GPX glutathione peroxidase -- GSK-3β glycogen synthase kinase-3 beta -- H2O2 hydrogen peroxide -- IGF insulin-like growth factor -- JNK c-jun N-terminal kinase -- KLHL12 Kelch-like 12 -- LiCl lithium chloride -- LRP5/6 lipoprotein receptor-related protein 5/6 -- MSCs mesenchymal stem cells -- NAC N-acetylcysteine -- NELL-1 Nel-like protein -- NO nitric oxide -- Nox NADPH oxidase -- NRX nucleoredoxin -- PCP planar cell polarity -- PKC protein kinase C -- PPARγ peroxisome proliferator-activated protein gamma -- PRXs peroxiredoxins -- ROS reactive oxygen species -- sFRPs secreted Frizzled-related proteins -- SOD superoxide dismutase -- TCF/LEF T cell factor/lymphoid-enhancing factor -- WIFI Wnt inhibitory factor 1 -- YAP1 Yes-associated protein 1; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2015.09.008
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that various signal transduction pathways and their interplay regulate MSC differentiation. To that end, a critical player in regulating MSC differentiation is a group of proteins encoded by the Wnt gene family, which was previously known for influencing various stages of embryonic development and cell fate determination. As MSCs have gained significant clinical attention for their potential applications in regenerative medicine, it is imperative to unravel the mechanisms by which molecular regulators control differentiation of MSCs for designing cell-based therapeutics. It is rather coincidental that the functional outcome(s) of Wnt-induced signals share similarities with cellular redox-mediated networks from the standpoint of MSC biology. Furthermore, there is evidence for a crosstalk between Wnt and redox signalling, which begs the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species. In this review, we summarize the impact of Wnt signalling on multi-lineage differentiation of MSCs, and attempt to unravel the intricate interplay between Wnt and redox signals.