GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions. (November 2015)

• Record Type: Journal Article
• Authors: Iorio, Andrea; Spinelli, Marina; Polimanti, Renato; Lorenzi, Federica; Valensise, Herbert; Manfellotto, Dario; Fuciarelli, Maria
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 194(2015:Nov.)
• Page Start: 34
• Page End: 37
• Publication Date: 2015-11
• Subjects: Gestation -- Detoxification -- Glutathione S-transferases -- Single nucleotide polymorphism -- Hypertension; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2015.08.006
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective(s): Glutathione S-transferases (GSTs) are the main phase II enzymes involved in the cellular detoxification. Through phase I and phase II detoxification reactions, the cell is able to detoxify endogenous and exogenous toxic compounds. In this study, we focused our attention on the GSTA1*-69C/T gene polymorphism (rs3957357) in order to explore its involvement in the genetic predisposition to gestational hypertension (GH). Study design: The case–control population consists of 195 subjects. The genotyping of the GSTA1*-69C/T was performed by using an RFLP-PCR technique. We calculated odds ratios (ORs), adjusted for the confounding variables, to estimate the association between GSTA1 and GH. Results: Significant allelic differences in GSTA1*-69C/T are present between GH women and pregnant women without cardiovascular complications ( p < 0.05). Specifically, we observed that the dominant genetic model best explains the observed genetic association, according to the Akaike information criterion and the Bayesian information criterion. Conclusion(s): Our study highlighted a significant association between the GSTA1 gene and the risk of GH in Italian patients. In particular, the -69C/T variant was significantly associated with disease risk. Since previous studies indicated that this GSTA1 polymorphism is associated with different pregnancy-related conditions, our finding supports the notion that GSTA1 may play a key role during pregnancy.