Copper(I)‐Catalysed Multicomponent Reaction: Straightforward Access to 5‐Hydroxy‐1H‐pyrrol‐2(5H)‐ones. Issue 4 (26th January 2016)

• Record Type: Journal Article
• Authors: Mardjan, Muhammad Idham Darussalam; Parrain, Jean‐Luc; Commeiras, Laurent
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 4(2016)
• Page Start: 543
• Page End: 548
• Publication Date: 2016-01-26
• Subjects: copper catalysis -- 5‐hydroxy‐1H‐pyrrol‐2(5H)‐ones -- multicomponent reaction; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500994
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalysed multicomponent coupling reaction between readily available ( Z )‐3‐iodoacrylic acids, terminal alkynes, and primary amines was developed to smoothly access a small library of 5‐hydroxy‐1 H ‐pyrrol‐2(5 H )‐ones in good yields. This practical and general process was applied to a short‐steps synthesis of the natural product pulchellalactam. Abstract :