Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer. (13th January 2016)

• Record Type: Journal Article
• Authors: Su, Jinghan; Sun, Huiping; Meng, Qingshuo; Yin, Qi; Tang, Shan; Zhang, Pengcheng; Chen, Yi; Zhang, Zhiwen; Yu, Haijun; Li, Yaping
• Is Part Of: Advanced functional materials. Volume 26:Number 8(2016)
• Page Start: 1243
• Page End: 1252
• Publication Date: 2016-01-13
• Subjects: biomimetic -- breast cancer -- long circulation -- metastasis -- nanoparticles -- tumor penetration; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201504780
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Limited blood circulation and poor tumor penetration are two main obstacles hampering the clinical translation of conventional nanosized drug delivery systems (NDDS). Here, red‐blood‐cell (RBC)‐mimetic nanoparticles (NPs) with long circulation and peptide‐enhanced tumor penetration for treating metastatic breast cancer are reported. The RBC‐mimetic NPs are composed of a paclitaxel (PTX)‐loaded polymeric core and a hydrophilic RBC vesicle shell. The RBC‐mimetic NPs display dramatically elongated blood circulation with an elimination half time of 32.8 h, 5.8‐fold higher than that of the parental polymeric NPs (i.e., 5.6 h). Moreover, the experimental results demonstrate that the tumor penetration ability of the RBC‐mimetic NPs can be significantly improved by coadministrating with a tumor‐penetrating peptide iRGD. Antitumor studies using a metastatic 4T1 breast tumor model show that RBC‐mimetic NPs in combination with iRGD significantly inhibit over 90% of the tumor growth and suppress 95% of the lung metastasis, much more efficient than PTX‐loaded polymer NP alone or the combination of polymer NPs and iRGD. The results reveal the importance of both long circulation and tumor penetration of nanosized drugs for efficient cancer therapy, which can provide a new insight for NDDS design. Abstract : Red‐blood‐cell (RBC)‐membrane wrapped nanoparticles (NPs) loading paclitaxel coadministrated with the tumor penetrating peptide iRGD can achieve deep penetration into tumor cell sites to inhibit lung metastasis of breast cancer. The penetration is enhanced compared to uncoated NPs or to NPs combined with iRGD or RBC membrane wrapping. The necessity of a long‐lasting delivery and a high tumor penetration ability of NPs for metastatic breast cancer treatment is demonstrated.