A Lysosome‐Targeting AIEgen for Autophagy Visualization. Issue 4 (20th December 2015)

• Record Type: Journal Article
• Authors: Leung, Chris Wai Tung; Wang, Zhiming; Zhao, Engui; Hong, Yuning; Chen, Sijie; Kwok, Ryan Tsz Kin; Leung, Anakin Chun Sing; Wen, Rongsen; Li, Bingshi; Lam, Jacky Wing Yip; Tang, Ben Zhong
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 4(2016)
• Page Start: 427
• Page End: 431
• Publication Date: 2015-12-20
• Subjects: aggregation‐induced emission -- autophagy -- lysosome imaging -- rapamycin; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500674
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In this work, a morpholine‐functionalized aggregation‐induced emission luminogen (AIEgen), AIE‐LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE‐LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE‐LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal‐to‐noise ratio, and high photostability.