Changing epidemiology of hepatocellular carcinoma in Asia. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Goh, George Boon-Bee; Chang, Pik-Eu; Tan, Chee-Kiat
• Is Part Of: Best practice & research. Volume 29:Issue 6(2015)
• Page Start: 919
• Page End: 928
• Publication Date: 2015-12
• Subjects: Hepatocellular carcinoma -- Hepatitis B -- Hepatitis C -- Aflatoxin -- Non-alcoholic steatohepatitis NASH -- Epidemiology; Gastroenterology -- Periodicals; Gastrointestinal system -- Diseases -- Periodicals; Gastrointestinal Diseases; Gastroenterology; Klinische geneeskunde; Gastro-enterologie; Gastroenterology; Gastrointestinal system -- Diseases; Periodicals; 616.33005
• DOI: 10.1016/j.bpg.2015.09.007
• Languages: English
• ISSNs: 1521-6918

Abstract

Abstract: Hepatocellular carcinoma is a major problem in Asia because of the presence of multiple risk factors in the region such as endemicity of hepatitis B and significant contamination of foodstuff by aflatoxin in some areas. Another risk factor for HCC, chronic hepatitis C infection, in Asia is most significant in Japan, the only Asian country with more HCV than HBV-related hepatocellular carcinoma. As these risk factors can and are being modified by measures such as universal hepatitis B immunisation, successful treatment of HCV infections, reduction and improved surveillance of aflatoxin contamination of foodstuff, it is not surprising that the epidemiology of HCC in Asia is changing. All these are offset by the rising importance of NAFLD and NASH as chronic liver diseases and risk factors for HCC which contributes to the changing epidemiology of HCC in Asia.