2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms. Issue 24 (15th December 2015)

• Record Type: Journal Article
• Authors: Cellier, Marie; Gignoux, Amandine; James, Arthur L.; Orenga, Sylvain; Perry, John D.; Robinson, Shaun N.; Stanforth, Stephen P.; Turnbull, Graeme
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 24(2015)
• Page Start: 5694
• Page End: 5698
• Publication Date: 2015-12-15
• Subjects: Nitroreductase -- Fluorescence -- Enzyme substrates -- Microorganism detection -- Bacterial detection; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.10.099
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.