A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Issue 24 (15th December 2015)

• Record Type: Journal Article
• Authors: Lee, Seoung Rak; Jung, Kiwon; Noh, Hyung Jun; Park, Yong Joo; Lee, Hye Lim; Lee, Kang Ro; Kang, Ki Sung; Kim, Ki Hyun
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 24(2015)
• Page Start: 5712
• Page End: 5715
• Publication Date: 2015-12-15
• Subjects: DNLCQLXPBPKXTD-UGYAIEHASA-N; Hericium erinaceus -- Hericiaceae -- Cerebroside -- Angiogenesis -- Nephrotoxicity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.10.092
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A new cerebroside, cerebroside E (1 ) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound1 in cancer treatment.