Protective effects of 5, 7, 4′-trihydroxy-6, 3′dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats. Issue 24 (15th December 2015)

• Record Type: Journal Article
• Authors: Panda, Sunanda; Kar, Anand
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 24(2015)
• Page Start: 5726
• Page End: 5728
• Publication Date: 2015-12-15
• Subjects: Thyrotoxicosis -- Protective effects -- Methoxy flavone -- Lipid peroxidation -- Annona squamosa; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.10.090
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Hitherto unknown protective effects of 5, 7, 4′-trihydroxy-6, 3′dimethoxy-flavone 5- O -α-l -rhamnopyranoside (THDMF-Rha); isolated from Annona squamosa leaves were evaluated inl -thyroxine (l -T4 )-induced thyrotoxicosis in rats. Administration ofl -T4 at 500 μg/kg body weight for 12 days increased the levels of serum thyroid hormones, the activity of 5′-monodeiodinase-I (5′DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of cellular antioxidants and serum lipids. However, administration of the isolated THDMF-Rha at a pre-standardized dose for 15 days ameliorated thel -T4 -induced alterations in the levels of thyroid hormones, hepatic LPO, G-6-Pase, 5′DI activity, and cellular levels of antioxidants and improved the status of different serum lipids, suggesting its antithyroidal and antioxidative potential. As compared to standard antithyroid drug, propylthiouracil, THDMF-Rha appeared to be more promising.