Electrofocusing-enhanced localized surface plasmon resonance biosensors. Issue 41 (15th September 2015)

• Record Type: Journal Article
• Authors: Zhang, Jinling; Wang, Yi; Wong, Ten It; Liu, Xiaohu; Zhou, Xiaodong; Liedberg, Bo
• Is Part Of: Nanoscale. Volume 7:Issue 41(2015)
• Page Start: 17244
• Page End: 17248
• Publication Date: 2015-09-15
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr03373j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : An electrofocusing-enhanced plasmonic sensor was developed on a gold nanohole array to promote the capture of human troponin I while repelling serum albumin. Abstract : Localized surface plasmon resonance (LSPR) biosensors typically suffer from diffusion limited mass transport and nonspecific adsorption upon detection of biomolecules in real biofluids. We employ here a peptide-modified plasmonic gold nanohole (AuNH) array for real-time detection of human troponin I (cTnI). Applying a negative electric bias on the AuNH sensor chip enables us to attract and concentrate cTnI at the sensor surface, while repelling other proteins thus decreasing interferences due to nonspecific adsorption.