A rapid and selective synthesis of α, α-fluorohalo esters via fluorohalogenative or difluorinative hydration of ynol ethers. Issue 93 (1st October 2015)

• Record Type: Journal Article
• Authors: Hu, Liang; Che, Chao; Tan, Ze; Zhu, Gangguo
• Is Part Of: Chemical communications. Volume 51:Issue 93(2015)
• Page Start: 16641
• Page End: 16644
• Publication Date: 2015-10-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07471a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Selectfluor-mediated fluorohalogenative or difluorinative hydration of ynol ethers is described, giving various α, α-fluorohalo esters including α, α-bromofluoro, α, α-chlorofluoro, α, α-fluoroiodo, and α, α-difluoro esters in a highly selective manner under mild reaction conditions. Abstract : A Selectfluor-mediated fluorohalogenative or difluorinative hydration of ynol ethers is described, giving various α, α-fluorohalo esters including α, α-bromofluoro, α, α-chlorofluoro, α, α-fluoroiodo, and α, α-difluoro derivatives in a highly selective manner under very mild reaction conditions. The resultant products can be applied to the facile synthesis of α-monofluoro-α-amino acids. This reaction represents a new advance in the trifunctionalization of alkynes.