Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy. Issue 93 (30th September 2015)

• Record Type: Journal Article
• Authors: Yano, Shigenobu; Naemura, Masami; Toshimitsu, Akio; Akiyama, Motofusa; Ikeda, Atsushi; Kikuchi, Jun-ichi; Shen, Xiande; Duan, Qian; Narumi, Atsushi; Inoue, Masahiro; Ohkubo, Kei; Fukuzumi, Shunichi
• Is Part Of: Chemical communications. Volume 51:Issue 93(2015)
• Page Start: 16605
• Page End: 16608
• Publication Date: 2015-09-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07353g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Glc-pendant C60 compounds exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids. Abstract : The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.