Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles. Issue 93 (5th October 2015)

• Record Type: Journal Article
• Authors: Misra, S. K.; Wang, X.; Srivastava, I.; Imgruet, M. K.; Graff, R. W.; Ohoka, A.; Kampert, T. L.; Gao, H.; Pan, D.
• Is Part Of: Chemical communications. Volume 51:Issue 93(2015)
• Page Start: 16710
• Page End: 16713
• Publication Date: 2015-10-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07709e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. Abstract : We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6–20 times more selective than the parent drugs.