Direct co-crystal assembly from synthesis to co-crystallization. Issue 47 (26th August 2015)

• Record Type: Journal Article
• Authors: Lee, Hung Lin; Lee, Tu
• Is Part Of: CrystEngComm. Volume 17:Issue 47(2015)
• Page Start: 9002
• Page End: 9006
• Publication Date: 2015-08-26
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c5ce01205h
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : The ternary phase diagram for the direct assembly of a 2 : 1 co-crystal of benzoic acid–sodium benzoate was illustrated. Benzoic acid acted as a reactant and underwent neutralization to produce sodium benzoate. The excessive amount of benzoic acid as an API can interact with the product, sodium benzoate as another API, to undertake API–API co-crystallization by cooling. Abstract : Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid–sodium benzoate.