Robust silver-mediated imidazolo-dC base pairs in metal DNA: dinuclear silver bridges with exceptional stability in double helices with parallel and antiparallel strand orientation. Issue 97 (14th October 2015)

• Record Type: Journal Article
• Authors: Jana, Sunit Kumar; Guo, Xiurong; Mei, Hui; Seela, Frank
• Is Part Of: Chemical communications. Volume 51:Issue 97(2015)
• Page Start: 17301
• Page End: 17304
• Publication Date: 2015-10-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc06734k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The silver-mediated imidazolo-dC base pair decorated with a furan residue forms exceptionally stable dinuclear silver bridges in DNA double helices with parallel and antiparallel chain orientation. Abstract : A new unprecedented metal-mediated base pair was designed that stabilizes reverse Watson–Crick DNA (parallel strand orientation, ps) as well as canonical Watson–Crick DNA (antiparallel strand orientation, aps). This base pair contains two imidazolo-dC units decorated with furan residues. T m measurements and spectroscopic studies reveal that each silver-mediated furano-imidazolo-dC forms exceptionally stable duplexes with ps and aps chain orientation. This stability increase by a silver-mediated base pair is the highest reported so far for ps and aps DNA helices.